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Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer

18 Mar 2024

Abstract excerpt

The global challenge posed by cancer, marked by rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. The PI3K/Akt signaling pathway, frequently amplified in various cancers, is central in regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, and resistance to...

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PMID: 38562143
DOI: 10.3389/fcell.2024.1372330

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