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Article

Targeting polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma

16 Jan 2023

Abstract excerpt

Radioresistance remains a major obstacle to efficacious radiotherapy in non-small-cell lung cancer (NSCLC). DNA replication proteins are novel targets for radiosensitizers. POLQ is a DNA polymerase involved in DNA damage response and repair. We found that POLQ is overexpressed in NSCLC and is clinically correlated with high tumor stage, poor prognosis, increased tumor mutational burden, and ALK and TP5 mutation...

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PMID: 36642785
DOI: 10.1111/cas.15727

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