Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beyond PARP—POLθ as an anticancer target

15 Mar 2018

Abstract excerpt

Targeting cancers dependent on DNA polymerase θ has considerable clinical potential

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29590065
DOI: 10.1126/science.aar5149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beyond PARP—POLθ as an anticancer targetPMID 29590065Read ↗

Targeting the DNA Repair Enzyme Polymerase θ in Cancer TherapySemantic proximity Read ↗

RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors.Semantic proximity Read ↗

Synthetic Lethality Targeting PolθSemantic proximity Read ↗

Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA RepairSemantic proximity Read ↗

Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma CellsSemantic proximity Read ↗

PARPi, BRCA, and gaps: controversies and future researchSemantic proximity Read ↗

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cellsSemantic proximity Read ↗

PARP and Cancer — If It's Broke, Don't Fix ItSemantic proximity Read ↗

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumorsSemantic proximity Read ↗

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.Semantic proximity Read ↗

DNA Polymerase ζ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic AgentsSemantic proximity Read ↗

Recent Progress in Poly(ADP–Ribose) Polymerase‐1 Inhibitors for Application in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.