Article
Targeting DNA polymerase ß for therapeutic intervention.
Current molecular pharmacology - 1 Jan 2012
Goellner Eva M, Svilar David, Almeida Karen H, Sobol Robert W
Abstract excerpt
DNA damage plays a causal role in numerous disease processes. Hence, it is suggested that DNA repair proteins, which maintain the integrity of the nuclear and mitochondrial genomes, play a critical role in reducing the onset of multiple diseases, including cancer, diabetes and neurodegeneration. As the primary DNA polymerase involved in base excision repair, DNA polymerase ß (Polß) has been implicated in multiple...
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