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Article

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?

Diabetologia - 1 Mar 2003

Hermann R, Knip M, Veijola R, Simell O, Laine A-P, Akerblom H K, Groop P-H, Forsblom C, Pettersson-Fernholm K, Ilonen J

Abstract excerpt

AIMS/HYPOTHESIS: The incidence of Type 1 diabetes has increased 2.5 times during the time period from 1966 to 2000 in Finland-a general trend seen in almost all developed countries that can only be explained by environmental factors. The aim of this study was to test the possible effect of a changing environment on distribution of genotypes associated with disease susceptibility. METHODS: HLA DRB1-DQA1-DQB1 genes...

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Identifiers

PMID: 12687342
DOI: 10.1007/s00125-003-1045-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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