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Article

Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis.

European journal of endocrinology - 1 Nov 2011

Hekkala Anne, Ilonen Jorma, Knip Mikael, Veijola Riitta

Abstract excerpt

OBJECTIVE: Our purpose was to assess whether family history of diabetes or the HLA-DR-DQ genotype of the index case was associated with the frequency of diabetic ketoacidosis (DKA) at diagnosis of childhood type 1 diabetes. PATIENTS AND METHODS: The study cohort comprised 1518 children aged <15 years and diagnosed with type 1 diabetes in Finland in 2002-2005. Family history of type 1 and type 2 diabetes among...

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Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1
Finland
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ Antigens

HLA-DR Antigens

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PMID: 21890652
DOI: 10.1530/EJE-11-0376

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Click a neighbor to travelStep 1 · 12 closest

Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis.PMID 21890652Read ↗

Diabetic ketoacidosis at diagnosis: role of family history and class II HLA genotypes.Semantic proximity Read ↗

Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children.Semantic proximity Read ↗

Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes.Semantic proximity Read ↗

Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosisSemantic proximity Read ↗

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.Semantic proximity Read ↗

Increased HLA class II risk is associated with a more aggressive presentation of clinical type 1 diabetes.Semantic proximity Read ↗

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes.Semantic proximity Read ↗

Extended family history of type 1 diabetes in HLA-predisposed children with and without islet autoantibodies.Semantic proximity Read ↗

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Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up.Semantic proximity Read ↗

Family history of type 2 diabetes delays development of type 1 diabetes in TEDDY children with islet autoimmunity.Semantic proximity Read ↗

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