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Article

2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype.

Neuroscience letters - 16 Feb 2023

Takei Rino, Nakashima Mari, Gotoh Mari, Endo Misaki, Hashimoto Kei, Miyamoto Yasunori, Murakami-Murofushi Kimiko

Abstract excerpt

2-carba-cyclic phosphatidic acid (2ccPA) suppresses microglial and astrocyte inflammation for neuronal survival following traumatic brain injury. However, it remains unknown how 2ccPA regulates microglial activation. In this study, to elucidate the 2ccPA behavior in glial communication, we collected the astrocyte conditioned media (ACM) from primary astrocyte cultures that were treated by lipopolysaccharide (LPS)...

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Identifiers

PMID: 36634888
DOI: 10.1016/j.neulet.2023.137063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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