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Article

Altered expression levels of IDH2 are involved in the development of colon cancer

20 Aug 2012

Abstract excerpt

IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production. Notably, this gene has been shown to be critical for cell proliferation. The abnormal expression of IDH2 has been reported in several types of cancer, and mutations in IDH2 have...

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Identifiers

PMID: 23226729
DOI: 10.3892/etm.2012.676

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