Discovery, implications and initial use of semi-synthetic organisms with an expanded genetic alphabet/code

Abstract excerpt

Abstract Much recent interest has focused on developing proteins for human use, such as in medicine. However, natural proteins are made up of only a limited number of canonical amino acids with limited functionalities, and this makes the discovery of variants with some functions difficult. The ability to recombinantly express proteins containing non-canonical amino acids (ncAAs) with properties selected to impart...

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