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Article

Amplification, mutation, and sequencing of a six-letter synthetic genetic system.

Journal of the American Chemical Society - 28 Sept 2011

Yang Zunyi, Chen Fei, Alvarado J Brian, Benner Steven A

Abstract excerpt

The next goals in the development of a synthetic biology that uses artificial genetic systems will require chemistry-biology combinations that allow the amplification of DNA containing any number of sequential and nonsequential nonstandard nucleotides. This amplification must ensure that the nonstandard nucleotides are not unidirectionally lost during PCR amplification (unidirectional loss would cause the...

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PMID: 21842904
DOI: 10.1021/ja204910n
PMCID: PMC3427765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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