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Donor and recipient polymorphisms of MAPK signaling pathway genes influence post-transplant liver function in Chinese liver transplant patients taking tacrolimus.

Gene - 20 Mar 2023

Niu Wanjie, Zheng Xinyi, Li Ziran, Wu Zhuo, Zhong Mingkang, Qiu Xiaoyan

Abstract excerpt

Tacrolimus (TAC) is an immunosuppressive drug that is widely used for patients who underwent liver transplantation. In addition to inhibiting the action of calcineurin, TAC also exerts its immunosuppressive effects by interfering with mitogen activated protein kinase (MAPK) pathway. In this study, we investigated the impact of both recipient and donor genetic polymorphisms of MAPK kinase kinase (MAP3K) genes on...

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PMID: 36632909
DOI: 10.1016/j.gene.2023.147190

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