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Article

Genetic and clinical determinants of mizoribine pharmacokinetics in renal transplant recipients.

European journal of clinical pharmacology - 1 Jan 2021

Dai Rui, Li Jingjie, Wu Jingjing, Fu Qian, Yan Jiajia, Zhong Guoping, Wang Changxi, Chen Xiao, Chen Pan

Abstract excerpt

AIM: Mizoribine (MZR) is an immunosuppressant for the prevention of allograft rejection in Asian countries, but the great variability in pharmacokinetics (PK) limits its clinical use. This study was to explore genetic and clinical factors that affect the MZR PK process. METHODS: Blood samples and clinical data were collected from 60 Chinese renal transplant recipients. MZR plasma concentration was measured at...

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PMID: 32803290
DOI: 10.1007/s00228-020-02936-7

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