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Article

Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer.

Journal of advanced research - 1 Sept 2023

Cheng Yanan, Bu Dechao, Zhang Qiaoling, Sun Rebecca, Lyle Stephen, Zhao Gang, Dong Li, Li Hui, Zhao Yi, Yu Jinpu, Hao Xishan

Abstract excerpt

INTRODUCTION: Gastric cancer (GC)is the third leading cause of cancer-related deaths in China and immunotherapy emerging as a revolutionary treatment for GC recently. Tumor mutational burden (TMB) is a predictive biomarker of immunotherapy in multiple cancers. However, the prognostic significance and subtype of TMB in GC is not fully understood. OBJECTIVES: This study aims to evaluate the prognostic value of TMB...

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Identifiers

PMID: 36351537
DOI: 10.1016/j.jare.2022.10.019
PMCID: PMC10491970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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