Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

K-Map: connecting kinases with therapeutics for drug repurposing and development.

Human genomics - 23 Sept 2013

Kim Jihye, Yoo Minjae, Kang Jaewoo, Tan Aik Choon

Abstract excerpt

UNLABELLED: Protein kinases play important roles in regulating signal transduction in eukaryotic cells. Due to evolutionary conserved binding sites in the catalytic domain of the kinases, most inhibitors that target these sites promiscuously inhibit multiple kinases. Quantitative analysis can reveal complex and unexpected interactions between protein kinases and kinase inhibitors, providing opportunities for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Drug Repositioning
Share to Internet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Theoretical

Share to Mutation

Share to Protein Kinases

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 24060470
DOI: 10.1186/1479-7364-7-20
PMCID: PMC3868238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K-Map: connecting kinases with therapeutics for drug repurposing and development.PMID 24060470Read ↗

Kinase Interaction Network Expands Functional and Disease Roles of Human KinasesSemantic proximity Read ↗

Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for ContributionsSemantic proximity Read ↗

The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer.Semantic proximity Read ↗

Polypharmacology is an enduring and nearly universal property of kinase inhibitorsSemantic proximity Read ↗

KinFams: De-Novo Classification of Protein Kinases Using CATH Functional UnitsSemantic proximity Read ↗

KLIFS: an overhaul after the first 5 years of supporting kinase researchSemantic proximity Read ↗

KinaseMD: kinase mutations and drug response database.Semantic proximity Read ↗

Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA).Semantic proximity Read ↗

Protein domain-based prediction of drug/compound–target interactions and experimental validation on LIM kinasesSemantic proximity Read ↗

KinCytE- a Kinase to Cytokine Explorer to Identify Molecular Regulators and Potential Therapeutic OpportunitiesSemantic proximity Read ↗

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugsSemantic proximity Read ↗

pyKinaXe: a fast and robust turnkey kinase activity profiler with high resolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.