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Article

STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence

28 Nov 2016

Abstract excerpt

Cytokines in the developing tumor microenvironment (TME) can drive transformation and subsequent progression toward metastasis. Elevated levels of the Interleukin-6 (IL-6) family cytokine Oncostatin M (OSM) in the breast TME correlate with aggressive, metastatic cancers, increased tumor recurrence, and poor patient prognosis. Paradoxically, OSM engages a tumor-suppressive, Signal Transducer and Activator of...

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Identifiers

PMID: 27892764
DOI: 10.1080/15384101.2016.1259037

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