Article
Age-specific effects of deletions: implications for aging theories.
Evolution; international journal of organic evolution - 23 Jan 2023
Brengdahl Martin I, Kimber Christopher M, Shenoi Vinesh Naresh, Dumea Miruna, Mital Avani, Friberg Urban
Abstract excerpt
The evolution of aging requires mutations with late-life deleterious effects. Classic theories assume these mutations either have neutral (mutation accumulation) or beneficial (antagonistic pleiotropy) effects early in life, but it is also possible that they start out as mildly harmful and gradually become more deleterious with age. Despite a wealth of studies on the genetics of aging, we still have a poor...
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