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Article

Some evolutionary consequences of deleterious mutations.

Genetica - 1 Jan 1998

Charlesworth B, Charlesworth D

Abstract excerpt

Most mutations with observable phenotypic effects are deleterious. Studies of Drosophila and inbred plant populations suggest that a new individual may have a mean number of new deleterious mutations that exceeds one-half. Most of these have relatively small homozygous effects and reduce fitness by 1-2% when heterozygous. Several striking features of present-day organisms have apparently evolved in response to...

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PMID: 9720268

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