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Article

Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer's disease.

Journal of neuroinflammation - 16 May 2015

Rosset Martine Bruley, Lui Gabrielle, Dansokho Cira, Chaigneau Thomas, Dorothée Guillaume

Abstract excerpt

BACKGROUND: Active immunization against Aβ was reported to have a therapeutic effect in murine models of Alzheimer's disease. Clinical Aβ vaccination trial AN1792 was interrupted due to the development in 6 % of the patients of meningoencephalitis likely involving pro-inflammatory CD4(+) T cells. However, the potential implication of auto-aggressive anti-Aβ CD8(+) T cells has been poorly investigated. METHODS:...

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Identifiers

PMID: 25982697
DOI: 10.1186/s12974-015-0317-5
PMCID: PMC4448209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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