Article
CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.
Cells - 22 Dec 2022
Key Jana, Gispert Suzana, Koornneef Lieke, Sleddens-Linkels Esther, Kohli Aneesha, Torres-Odio Sylvia, Koepf Gabriele, Amr Shady, Reichlmeir Marina, Harter Patrick N, West Andrew Phillip, Münch Christian, Baarends Willy M, Auburger Georg
Abstract excerpt
Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix peptidase CLPP, which trigger additional azoospermia. Here, we analyzed the impact of CLPP deficiency on male mouse meiosis stages. Histology, immunocytology, different OMICS and biochemical approaches, and RT-qPCR were employed in...
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