Article
Effect of sulfadoxine-pyrimethamine chemoprophylaxis in pregnant women on selection of the new P. falciparum dhps quintuple mutant carrying the I431V mutation.
The Journal of antimicrobial chemotherapy - 2 Mar 2023
Cohen Olivia, Guemas Emilie, Menard Sandie, Tsague Kenfack Martial, Talom Ngassa Carine, Iriart Xavier, Bidzogo Lebobo Marlise, Ondobo Ekae Celestin, Eboumbou Carole, Tiyou Kenmeni Calvin, Berry Antoine
Abstract excerpt
BACKGROUND: A new mutation in the Plasmodium falciparum dihydropteroate synthetase gene (pfdhps), I431V, has been identified in several countries of Central and West Africa. This mutation is mostly found in association with four other SNPs on pfdhps (S436A, A437G, A581G and A613S), forming a quintuple mutant (vagKgs) and almost always associated with the Plasmodium falciparum dihydrofolate reductase gene (pfdhfr)...
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