A novel intron variant is associated with emerging pfdhps mutant haplotypes in West and Central African Plasmodium falciparum.

doi:10.1016/j.ijpddr.2025.100611

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Article

A novel intron variant is associated with emerging pfdhps mutant haplotypes in West and Central African Plasmodium falciparum.

International journal for parasitology. Drugs and drug resistance - 1 Dec 2025

Hocke Emma Filtenborg, Hansson Helle, Chopo-Pizarro Ana, Adegbola Adebanjo Jonathan, Bolaji Oluseye, Ngwa Niba Peter Thelma, Ali Innocent Mbulli, Nji Akindeh, Mbacham Wilfred, Baraka Vito, Kulaya Neema B, Kahunu Gauthier Mesia, Mavoko Hypolite Muhindo, Nkoli Papy Mandoko, Sompwe Eric Mukomena, Mbongi Destin, Mitashi Patrick, Bédia Valérie A, Gnagne Paterne A, Konaté Abibatou, Yavo William, Menan Hervé, Beshir Khalid, Mousa Andria, Sutherland Colin J, Alifrangis Michael, Roper Cally

Abstract excerpt

Sulfadoxine-pyrimethamine plays a key role in Plasmodium falciparum chemoprevention across Africa, yet the protective efficacy of SP is undermined by mutations conferring resistance in the genes encoding dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps). The emergence and spread of the pfdhps 431V mutation suggests that this may confer resistance and be selected by drug use. Here, we report a...

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PMID: 40882319
DOI: 10.1016/j.ijpddr.2025.100611
PMCID: PMC12410353

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