Article
Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana.
The Journal of infectious diseases - 15 Nov 2008
Mockenhaupt Frank P, Bedu-Addo George, Eggelte Teunis A, Hommerich Lena, Holmberg Ville, von Oertzen Christa, Bienzle Ulrich
Abstract excerpt
Use of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) has become policy in much of sub-Saharan Africa but crucially depends on the efficacy of SP. We assessed the frequency of the dhfr triple mutation among Plasmodium falciparum isolates obtained from pregnant Ghanaian women in 1998, 2000, and 2006. The prevalence of the triple mutation, which confers resistance...
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