Article
Mutational analysis of DNMT3A improves the prognostic stratification of patients with acute myeloid leukemia.
Cancer science - 1 Apr 2023
Wakita Satoshi, Marumo Atsushi, Morita Kaoru, Kako Shinichi, Toya Takashi, Najima Yuho, Doki Noriko, Kanda Junya, Kuroda Junya, Mori Shinichiro, Satake Atsushi, Usuki Kensuke, Ueki Toshimitsu, Uoshima Nobuhiko, Kobayashi Yutaka, Kawata Eri, Nakayama Kazutaka, Nagao Yuhei, Shono Katsuhiro, Shibusawa Motoharu, Tadokoro Jiro, Hagihara Masao, Uchiyama Hitoji, Uchida Naoyuki, Kubota Yasushi, Kimura Shinya, Nagoshi Hisao, Ichinohe Tatsuo, Kurosawa Saiko, Motomura Sayuri, Hashimoto Akiko, Muto Hideharu, Sato Eriko, Ogata Masao, Mitsuhashi Kenjiro, Ando Jun, Tashiro Haruko, Sakaguchi Masahiro, Yui Shunsuke, Arai Kunihito, Kitano Tomoaki, Miyata Miho, Arai Haruka, Kanda Masayuki, Itabashi Kako, Fukuda Takahiro, Kanda Yoshinobu, Yamaguchi Hiroki
Abstract excerpt
Nucleophosmin1 (NPM1) mutations are the most frequently detected gene mutations in acute myeloid leukemia (AML) and are considered a favorable prognostic factor. We retrospectively analyzed the prognosis of 605 Japanese patients with de novo AML, including 174 patients with NPM1-mutated AML. Although patients with NPM1-mutated AML showed a high remission rate, this was not a favorable prognostic factor for...
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