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Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies

1 Jan 2014

Abstract excerpt

Induced pluripotent stem cell (iPSC) therapies offer a promising path for patient-specific regenerative medicine. However, tumor formation from residual undifferentiated iPSC or transformation of iPSC or their derivatives is a risk. Inclusion of a suicide gene is one approach to risk mitigation. We introduced a dimerizable-"inducible caspase-9" (iCasp9) suicide gene into mouse iPSC (miPSC) and rhesus iPSC...

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PMID: 26052521
DOI: 10.1038/mtm.2014.53

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