Humanization of the Shark VNAR Single Domain Antibody Using CDR Grafting

Abstract excerpt

Abstract The variable domain of the new antigen receptor (VNAR) of shark single domain antibodies is evolutionarily distant from the variable regions (VH) of mammalian immunoglobulins, yet it still has complementarity‐determining regions (CDRs) that are involved in antigen recognition, therefore making it possible to humanize by grafting these CDRs to the framework of human VH homologs. Here, we show the VNAR CDR...

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