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Article

Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.

Nature medicine - 1 Apr 2023

Watanabe Kengo, Wilmanski Tomasz, Diener Christian, Earls John C, Zimmer Anat, Lincoln Briana, Hadlock Jennifer J, Lovejoy Jennifer C, Gibbons Sean M, Magis Andrew T, Hood Leroy, Price Nathan D, Rappaport Noa

Abstract excerpt

Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic diseases. Here we report an atlas of cross-sectional and longitudinal changes in 1,111 blood analytes associated with variation in body mass index (BMI), as well as multiomic associations with host polygenic risk scores and gut...

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Identifiers

PMID: 36941332
DOI: 10.1038/s41591-023-02248-0
PMCID: PMC10115644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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