Article
Maternally transmitted aminoglycoside-induced and non-syndromic hearing loss caused by the 1494C > T mutation in the mitochondrial 12S rRNA gene in two Chinese families.
International journal of audiology - 1 Feb 2013
Wei Qinjun, Xu Dan, Chen Zhibin, Li Haifeng, Lu Yajie, Liu Cheng, Bu Xingkuan, Xing Guangqian, Cao Xin
Abstract excerpt
OBJECTIVE: To explore the molecular genetic characterization of two Chinese families with aminoglycoside-induced and non-syndromic hearing loss (NSHL). DESIGN: Clinical evaluations, sequence analysis of mitochondrial DNA (mtDNA) as well as two nuclear genes TRMU and MTO1 encoding mitochondrial proteins. STUDY SAMPLE: Two Chinese families with aminoglycoside-induced and NSHL. RESULTS: Clinical evaluations revealed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.