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Article

Screening for mitochondrial 12S rRNA C1494T mutation in 655 patients with non-syndromic hearing loss: An observational study.

Medicine - 1 Mar 2020

Gao Zhen, Yuan Ya-Sheng

Abstract excerpt

Mutations in mitochondrial DNA, especially in 12S rRNA gene, are the most important causes for hearing loss. In particular, the A1555G and C1494T mutations have been found to be associated with both aminoglycoside-induced and non-syndromic hearing loss in many families worldwide. To determine the frequency of C1494T mutation in deaf patients, in the current study, we screened this mutation in 655 patients with...

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Identifiers

PMID: 32221064
DOI: 10.1097/MD.0000000000019373
PMCID: PMC7220552

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