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Article

Rapid identification of aminoglycoside-induced deafness gene mutations using multiplex real-time polymerase chain reaction.

International journal of pediatric otorhinolaryngology - 1 Jul 2015

Huang Shasha, Xiang Guangxin, Kang Dongyang, Wang Chen, Kong Yanling, Zhang Xun, Liang Shujian, Mitchelson Keith, Xing Wanli, Dai Pu

Abstract excerpt

BACKGROUND: Exposure to aminoglycoside antibiotics can induce ototoxicity in genetically susceptible individuals carrying certain mitochondrial DNA (mtDNA) mutations (C1494T and A1555G), resulting in hearing loss. So, a rapid diagnostic approach is needed to accurately identify subjects carrying such gene mutations. METHODS: In the present study, we describe a rapid and reliable four-color, real-time quantitative...

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Share to DNA, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25959403
DOI: 10.1016/j.ijporl.2015.04.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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