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Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia

28 Dec 2022

Abstract excerpt

Somatic genome abnormality is a hallmark of B-cell acute lymphoblastic leukemia (B-ALL) with implications in disease diagnosis and risk stratification. 1 Similarly, germline genetic variants in several genes such as TP53, ETV6, PAX5, or IKZF1 have also been associated with the biology of B-ALL and its prognosis.[2][3][4][5] Transcription factor 3 (TCF3) gene fusion with PBX1 or HLF1 are common somatic alterations...

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PMID: 36576946
DOI: 10.1182/bloodadvances.2022008563

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