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Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence

1 May 2017

Abstract excerpt

Viral latency, in which a virus genome does not replicate independently of the host cell genome and produces no infectious particles, is required for long-term virus persistence. There is no known latency mechanism for chronic small DNA virus infections. Merkel cell polyomavirus (MCV) causes an aggressive skin cancer after prolonged infection and requires an active large T (LT) phosphoprotein helicase to...

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PMID: 28461484
DOI: 10.1073/pnas.1703879114

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