Article
A novel mutation in the TSC2 gene protects against colorectal cancer in the Mexican population.
Gaceta medica de Mexico - 1 Jan 2022
González-Villaseñor Christian O, Ramírez-Guerrero Angélica A, Moreno-Ortiz José M, Leal-Ugarte Evelia, Peralta-Leal Valeria, Macías-Gómez Nelly M
Abstract excerpt
INTRODUCTION: Colorectal cancer (CRC) is a complex disease due to the large number of factors that influence its development, including variants in tumor suppressor genes. OBJECTIVE: To estimate allelic and genotypic frequencies of c.3915G>A and c.5371G>A variants of the TSC2 gene in a Mexican population with CRC, as well as to analyze their association with the development of CRC. METHODS: 126 peripheral blood...
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