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Distinct Driver Pathway Enrichments and a High Prevalence of TSC2 Mutations in Right Colon Cancer in Chile: A Preliminary Comparative Analysis.

International journal of molecular sciences - 25 Apr 2024

Tapia-Valladares Camilo, Valenzuela Guillermo, González Evelin, Maureira Ignacio, Toro Jessica, Freire Matías, Sepúlveda-Hermosilla Gonzalo, Ampuero Diego, Blanco Alejandro, Gallegos Iván, Morales Fernanda, Erices José I, Barajas Olga, Ahumada Mónica, Contreras Héctor R, González Jaime, Armisén Ricardo, Marcelain Katherine

Abstract excerpt

Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While ethnic differences in driver gene mutations have been documented, the South American population remains understudied at the genomic level, despite facing a rising burden of CRC. We analyzed tumors of 40 Chilean CRC patients (Chp) using next-generation sequencing and compared them to data from mainly Caucasian cohorts (TCGA and...

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PMID: 38731914
DOI: 10.3390/ijms25094695
PMCID: PMC11083322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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