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Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers

28 Mar 2019

Abstract excerpt

Abstract Background It is often assumed any cancer in a germline BRCA1 or BRCA2 (collectively termed BRCA) mutation carrier was caused by that mutation. It is also often assumed the occurrence of breast or ovarian cancer in an individual with a variant of uncertain significance (VUS) suggests the VUS is pathogenic. These assumptions have profound management implications for cancer patients and healthy...

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PMID: 31360904
DOI: 10.1093/jncics/pkz028

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