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Article

Breast and Ovarian Cancer Among Individuals Undergoing BRCA1 and BRCA2 Testing.

JAMA network open - 1 Jul 2026

Dossa Fahima, Metcalfe Kelly, Ante Zharmaine, Liu Ning, Lerner-Ellis Jordan, Eisen Andrea, Baxter Nancy N

Abstract excerpt

Importance: Pathogenic variants in BRCA1 and BRCA2 confer substantial risks of breast and ovarian cancer; however, risk for female individuals undergoing testing, particularly those with variants of uncertain significance (VUS) or negative results, remain poorly defined. Objective: To estimate lifetime incidence of breast and ovarian cancer among female individuals undergoing BRCA1 or BRCA2 testing across all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42530926
DOI: 10.1001/jamanetworkopen.2026.26334
PMCID: PMC13425191

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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