Article
A Novel Approach to Detect IDH Point Mutations in Gliomas Using Nanopore Sequencing: Test Validation for the Clinical Laboratory.
The Journal of molecular diagnostics : JMD - 1 Mar 2023
Mimosa Mashiat L, Al-Ameri Wafa, Simpson Jared T, Nakhla Michael, Boissinot Karel, Munoz David G, Das Sunit, Feilotter Harriet, Fattouh Ramzi, Saleeb Rola M
Abstract excerpt
The use of standard next-generation sequencing technologies to detect key mutations in IDH genes for glioma diagnosis imposes several challenges, including high capital cost and turnaround delays associated with the need for batch testing. For both glioma testing and testing in other tumor types where highly specific mutation identification is required, the high-throughput nature of next-generation sequencing...
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