Article
Germline and somatic mutations in the pathology of pineal cyst: A whole-exome sequencing study of 93 individuals.
Molecular genetics & genomic medicine - 1 Jun 2021
Yan Yuanqing, Martinez Rebecca, Rasheed Maria N, Cahal Joshua, Xu Zhen, Rui Yanning, Qualmann Krista J, Hagan John P, Kim Dong H
Abstract excerpt
BACKGROUND: Pineal cyst is a benign lesion commonly occurring in people of any age. Until now, the underlying molecular alterations have not been explored. METHODS: We performed whole exome sequencing of 93 germline samples and 21 pineal cyst tissue samples to illustrate its genetic architecture and somatic mutations. The dominant and recessive inheritance modes were considered, and a probability was calculated...
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