A rare variant in EZH2 is associated with prostate cancer risk.

doi:10.1002/ijc.33584

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A rare variant in EZH2 is associated with prostate cancer risk.

International journal of cancer - 1 Sept 2021

Raspin Kelsie, FitzGerald Liesel M, Marthick James R, Field Matt A, Malley Roslyn C, Banks Annette, Donovan Shaun, Thomson Russell J, Foley Georgea R, Stanford Janet L, Dickinson Joanne L

Abstract excerpt

Prostate cancer (PrCa) is highly heritable, and although rare variants contribute significantly to PrCa risk, few have been identified to date. Herein, whole-genome sequencing was performed in a large PrCa family featuring multiple affected relatives spanning several generations. A rare, predicted splice site EZH2 variant, rs78589034 (G > A), was identified as segregating with disease in all but two individuals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tasmania

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Transcriptome

Share to Enhancer of Zeste Homolog 2 Protein

Share to Follow-Up Studies

Share to Gene Expression Regulation, Neoplastic

Share to Prostatic Neoplasms

Share to Tumor Cells, Cultured

Share to United States

Source

Open in PubMed

Identifiers

PMID: 33821477
DOI: 10.1002/ijc.33584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A rare variant in EZH2 is associated with prostate cancer risk.PMID 33821477Read ↗

Association Study of Over 200,000 Subjects Detects Novel Rare Variants, Functional Elements, and Polygenic Architecture of Prostate Cancer SusceptibilitySemantic proximity Read ↗

Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.Semantic proximity Read ↗

Germline sequencing of DNA-damage-repair genes in two hereditary prostate cancer cohorts reveals new disease risk-associated gene variantsSemantic proximity Read ↗

A Comprehensive Investigation of Genomic Variants in Prostate Cancer Reveals 30 Putative Regulatory Variants.Semantic proximity Read ↗

Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival.Semantic proximity Read ↗

Characterising the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 casesSemantic proximity Read ↗

Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.Semantic proximity Read ↗

Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.Semantic proximity Read ↗

Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.Semantic proximity Read ↗

Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.Semantic proximity Read ↗

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanismsSemantic proximity Read ↗

Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.