Article
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.
Scientific reports - 20 Oct 2020
Lim Wei-Wen, Corden Ben, Ng Benjamin, Vanezis Konstantinos, D'Agostino Giuseppe, Widjaja Anissa A, Song Wei-Hua, Xie Chen, Su Liping, Kwek Xiu-Yi, Tee Nicole G Z, Dong Jinrui, Ko Nicole S J, Wang Mao, Pua Chee Jian, Jamal Muhammad H, Soh Beeyong, Viswanathan Sivakumar, Schafer Sebastian, Cook Stuart A
Abstract excerpt
Transforming growth factor beta-1 (TGFβ1) is a major driver of vascular smooth muscle cell (VSMC) phenotypic switching, an important pathobiology in arterial disease. We performed RNA-sequencing of TGFβ1-stimulated human aortic or arterial VSMCs which revealed large and consistent upregulation of Interleukin 11 (IL11). IL11 has an unknown function in VSMCs, which highly express the IL11 receptor alpha, suggestive...
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