Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with aortic aneurysm.

Molecular medicine reports - 1 Oct 2017

Qin Wei, Cao Yide, Li Liangpeng, Chen Wen, Chen Xin

Abstract excerpt

Aortic aneurysm (AA) remains a fatal condition with high rates of morbidity and mortality, and the associated underlying mechanism influencing its pathology remains to be elucidated. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑7 has previously been demonstrated to be involved in the pathogenesis of vascular atherosclerosis via degradation of cartilage oligomeric matrix protein (COMP)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen
Share to Aortic Aneurysm
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage Oligomeric Matrix Protein

Share to Matrix Metalloproteinase 9

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 28849199
DOI: 10.3892/mmr.2017.7293
PMCID: PMC5647091

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with aortic aneurysm.PMID 28849199Read ↗

ADAMs family and relatives in cardiovascular physiology and pathology.Semantic proximity Read ↗

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology.Semantic proximity Read ↗

Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinical implications of a pilot study.Semantic proximity Read ↗

The role of ADAMTSs in arthritisSemantic proximity Read ↗

Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine ModelSemantic proximity Read ↗

Potential function of microRNAs in thoracic aortic aneurysm and thoracic aortic dissection pathogenesis.Semantic proximity Read ↗

ADAMTS proteases in cardiovascular physiology and diseaseSemantic proximity Read ↗

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways.Semantic proximity Read ↗

Altered Patterns of Gene Expression Specific to Thoracic Aortic Aneurysms: Microarray Analysis of Surgically Resected SpecimensSemantic proximity Read ↗

The pivotal role of matrix metalloproteinases in the development of human abdominal aortic aneurysms.Semantic proximity Read ↗

AT2R agonist NP-6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm.Semantic proximity Read ↗

[Pathobiology of idiopathic ascending aortic aneurysms].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.