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New Insights into the Mechanism of Antibacterial Action of Synthetic Peptide Mo-CBP3-PepI against Klebsiella pneumoniae

4 Dec 2022

Abstract excerpt

Klebsiella pneumoniae is a multidrug-resistant opportunistic human pathogen related to various infections. As such, synthetic peptides have emerged as potential alternative molecules. Mo-CBP3-PepI has presented great activity against K. pneumoniae by presenting an MIC50 at a very low concentration (31.25 µg mL−1). Here, fluorescence microscopy and proteomic analysis revealed the alteration in cell membrane...

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PMID: 36551410
DOI: 10.3390/antibiotics11121753

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