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BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms

22 Dec 2022

Abstract excerpt

The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for BAP1 in mitotic progression highlighting the relationship between BAP1 and control of genome stability in mesothelioma cells with therapeutic implications. Depletion of BAP1 protein induced proteasome-mediated degradation of BRCA1 in mesothelioma cells while loss...

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PMID: 36550359
DOI: 10.1038/s41388-022-02577-3

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