Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r].

Sheng li xue bao : [Acta physiologica Sinica] - 25 Feb 2017

Fei Fei, Sun Shao-Yang, Yao Yu-Xiao, Wang Xu

Abstract excerpt

Obesity has become a severe public health problem across the world, and seriously affects the health and life quality of human beings. Here we generated lepr and mc4r mutant zebrafish via the CRISPR/Cas9 technique, and performed morphological and functional characterizations of those mutants. We observed that there was no significant phenotypic difference between homozygous mutants and wild-type controls before...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Leptin

Share to Receptor, Melanocortin, Type 4

Share to Receptors, Leptin

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 28217809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r].PMID 28217809Read ↗

Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafishSemantic proximity Read ↗

CRISPR-Cas9-mediated generation of obese and diabetic mouse models.Semantic proximity Read ↗

Zebrafish as a Model for Obesity and DiabetesSemantic proximity Read ↗

Mutations in melanocortin-4 receptor: From fish to men.Semantic proximity Read ↗

Obese zebrafish: A small fish for a major human health conditionSemantic proximity Read ↗

Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesitySemantic proximity Read ↗

Effects of Nutritionally Induced Obesity on Metabolic Pathways of ZebrafishSemantic proximity Read ↗

Genomic knockout of <i>alms1</i> in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypesSemantic proximity Read ↗

Leptin and Its Signaling Are Not Involved in Zebrafish Puberty OnsetSemantic proximity Read ↗

The emerging use of zebrafish to model metabolic disease.Semantic proximity Read ↗

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.Semantic proximity Read ↗

Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.