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CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives

1 Jan 2022

Abstract excerpt

CRISPR-Cas9 is a Nobel Prize-winning robust gene-editing tool developed in the last decade. This technique enables a stable genetic engineering method with high precision on the genomes of all organisms. The latest advances in the technology include a genome library screening approach, which can detect survival-essential and drug resistance genes via gain or loss of function. The versatile machinery allows...

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PMID: 35547744
DOI: 10.7150/thno.71144

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