Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in mice

11 Apr 2014

Abstract excerpt

BACKGROUND: The adverse effects on offspring of diabetic and/or obese mothers can be passed to the next generation. However, the mechanisms behind this are still unclear. Epigenetics may play a key role during this process. METHODS: To confirm the hypothesis, we investigated the DNA methylation of several imprinted genes in spermatozoa of offspring from diabetic and/or obese mothers utilizing streptozotocin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24721882
DOI: 10.1186/1477-7827-12-29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in micePMID 24721882Read ↗

Maternal Diabetes Mellitus and the Origin of Non-Communicable Diseases in Offspring: The Role of Epigenetics1Semantic proximity Read ↗

High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male ratsSemantic proximity Read ↗

Whole genome bisulfite sequencing of human spermatozoa reveals differentially methylated patterns from type 2 diabetic patients.Semantic proximity Read ↗

Paternal obesity induces epigenetic aberrations and gene expression changes in placenta and fetusSemantic proximity Read ↗

Epigenetic Regulation of Obesity-Associated Type 2 DiabetesSemantic proximity Read ↗

Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?Semantic proximity Read ↗

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspringSemantic proximity Read ↗

Epigenetics Plays a Role in the Pathogenesis and Treatment of DiabetesSemantic proximity Read ↗

DNA methylation in obesity and type 2 diabetesSemantic proximity Read ↗

Epigenetic modifications in pancreas development, diabetes, and therapeutics.Semantic proximity Read ↗

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetesSemantic proximity Read ↗

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.