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Article

Biology and therapeutic targeting of molecular mechanisms in MPNs.

Blood - 20 Apr 2023

How Joan, Garcia Jacqueline S, Mullally Ann

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by activated Janus kinase (JAK)-signal transducer and activator of transcription signaling. As a result, JAK inhibitors have been the standard therapy for treatment of patients with myelofibrosis (MF). Although currently approved JAK inhibitors successfully ameliorate MPN-related symptoms, they are not known to...

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Identifiers

PMID: 36534936
DOI: 10.1182/blood.2022017416
PMCID: PMC10163317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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