Article
Biology and Current Treatment of Myeloproliferative Neoplasms.
Cancer treatment and research - 1 Jan 2021
Ali Haris, Pullarkat Vinod, Snyder David
Abstract excerpt
The classical myeloproliferative neoplasms (MPN) are characterized by clonal expansion of one or more hematopoietic cell lineages and are driven by mutations that activate constitutive signaling via JAK2 pathway. The criteria for diagnosis have now been defined by the World Health Organization (WHO) and the term MPN as is currently used encompasses the entities of primary myelofibrosis, polycythemia vera, and...
Topics
- Biology
- Humans
- Mutation
- Myeloproliferative Disorders
- Polycythemia Vera
- Primary Myelofibrosis
- Thrombocythemia, Essential