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Article

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure.

Asian journal of andrology - 1 Mar 2024

Che Jian-Fang, Wu Hui-Xia, Zeng Si-Cong, Wu Yue-Ren, Dai Jing, Cheng De-Hua, Gong Fei, Lu Guang-Xiu, Lin Ge, Dai Can

Abstract excerpt

Phospholipase C zeta (PLCζ) is a key sperm-borne oocyte-activating factor that triggers Ca 2+ oscillations and the subsequent block to polyspermy following gamete fusion. Mutations in PLCZ1 , the gene encoding PLCζ, cause male infertility and intracytoplasmic sperm injection (ICSI) fertilization failure; and PLCζ expression and localization patterns are significantly correlated with ICSI fertilization rate (FR)....

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Share to Fertilization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

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Share to Phosphoinositide Phospholipase C

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Share to Sperm Injections, Intracytoplasmic

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Source

Open in PubMed Open full text

Identifiers

PMID: 38048167
DOI: 10.4103/aja202355
PMCID: PMC10919416

Genes

PLCZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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