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Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.

Human reproduction (Oxford, England) - 29 Feb 2020

Yan Zheng, Fan Yong, Wang Fei, Yan Zhiguang, Li Menghui, Ouyang Jie, Wu Ling, Yin Mingru, Zhao Jilang, Kuang Yanping, Li Bin, Lyu Qifeng

Abstract excerpt

STUDY QUESTION: Do sperm-specific phospholipase C zeta (PLCZ1) mutations account for male infertility due to fertilization failure? SUMMARY ANSWER: Six novel mutations and one reported mutation in PLCZ1 were identified in five of 14 independent families characterized by fertilization failure or poor fertilization, suggesting that these mutations may be responsible for fertilization failure in men exhibiting...

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PMID: 32048714
DOI: 10.1093/humrep/dez282

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