Article
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.
Nature communications - 17 Dec 2022
Li Juan, Wang Yang, Luo Yue, Liu Yang, Yi Yong, Li Jinsong, Pan Yang, Li Weiyuxin, You Wanbang, Hu Qingyong, Zhao Zhiqiang, Zhang Yujun, Cao Yang, Zhang Lingqiang, Yuan Junying, Xiao Zhi-Xiong Jim
Abstract excerpt
Non-small cell lung cancers (NSCLC) frequently contain KRAS mutation but retain wild-type TP53. Abundant senescent cells are observed in premalignant but not in malignant tumors derived from the Kras-driven mouse model, suggesting that KRAS oncogenic signaling would have to overcome the intrinsic senescence burden for cancer progression. Here, we show that the nuclear Beclin 1-mediated inhibition of p53-dependent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.